EXHIBIT 32.1

Pursuant to 18 U.S.C. § 1350, each of the undersigned hereby certifies in his capacity as an officer of Northpointe Bancshares, Inc. (the "Company") that the Annual Report of the Company on Form 10-Q for the accounting period ended December 31, 2025 fully complies with the requirements of Section 13(a) or Section 15(d)of the Securities Exchange Act of 1934 and that the information contained in such report fairly presents, in all material respects, the financial condition of the Company at the end of such period and the results of operations of the Company for such period.

						/s/ Charles A. Williams
						Charles A. Williams
						Chairman and Chief Executive Officer
						/s/  Bradley T. Howes
						Bradley T. Howes
						Executive Vice President and Chief Financial Officer
Date:			March 27, 2026